Therapeutic proteins
biotherapeutic
ADME/PK studie
ADME/PK studie
Our impact on preclinical development
Combined with mass spectrometry analysis, the PSAQ™ method significantly increases the performance and reliability of biotherapeutic ADME/PK studies.
Advantages • Fast assay development
• Excellent specificity and sensitivity
• Excellent accuracy and precision
• Suited to complex matrices analysis
• Avoid the use of antibodies
• No interference from induced antibodies for circulating target
• No interference from non-specific protein binding
Our services• Engineering and manufacturing of stable-isotope-labeled therapeutic proteins to be used as PSAQ quantification standards or to be administered in vivo
• Development of quantitative mass spectrometry assays (SRM analysis) and sample analysis
Method
1. We synthesize your therapeutic protein in a stable isotope-labeled form (PSAQ™ standard)
2. We quantify your therapeutic protein in biofluids and tissues
Advantages • Fast assay development
• Excellent specificity and sensitivity
• Excellent accuracy and precision
• Suited to complex matrices analysis
• Avoid the use of antibodies
• No interference from induced antibodies for circulating target
• No interference from non-specific protein binding
Our services• Engineering and manufacturing of stable-isotope-labeled therapeutic proteins to be used as PSAQ quantification standards or to be administered in vivo
• Development of quantitative mass spectrometry assays (SRM analysis) and sample analysis
Method1. We synthesize your therapeutic protein in a stable isotope-labeled form (PSAQ™ standard)
2. We quantify your therapeutic protein in biofluids and tissues